Associate Scientist, In Vitro Biology

Work Requirement

This position will report to the Scientist & Group Lead, In Vitro Biology, ADC Therapeutic Development and will be based full time onsite in Vancouver, BC office.

Key Responsibilities

• Oversees the design, coordination, execution, and analysis of in vitro pharmacology experiments for the screening and progression of novel technologies for ADCs.
• Functionally characterizes small molecules, antibodies, bioconjugates, or ADCs using various cell-based assays and techniques including flow cytometry, high throughput screening, live cell imaging, 3D tissue culture, and other methods as required to support pipeline project advancement.
• Leads and executes novel assay development initiatives. Designs and troubleshoots novel methods to profile the mechanism of action of ADCs across multiple payload classes.
• Applies knowledge of cancer biology, medicinal chemistry, and other scientific methodologies in conducting technically advanced analyses and data interpretations.
• Effectively collaborates with members outside of their immediate team to coordinate execution of decision-making experiments for different projects and routinely shares progress updates with the team.
• Prepares and disseminates data presentations for group meetings, summarizing results and next steps. Acts as area representative in specific projects.
• Provides leadership, mentorship, and scientific/technical guidance to junior staff.
• Supports mammalian tissue culture activities within the group. Works with team to ensure cell lines are properly expanded, cryopreserved and databases updated as required.
• May co-author or author scientific papers, conference disclosures, patents, and/or regulatory documents.
• May present at relevant scientific conferences on behalf of Zymeworks
• Adheres to Zymeworks standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic laboratory notebook.
• Conducts all activities in accordance with scientific standards, OS&H regulations and established Zymeworks' policies and practices. Contributes to a safe and highly efficient laboratory environment.
• Actively works to foster an environment of effective and collaborative working relationships amongst employees, management, and external partners.
  

Education and Experience

• Associate Scientist: Requires a PhD in Molecular Biology, Immunology, Biochemistry with a minimum 1-2 years' relevant work experience, or equivalent combination of education and work experience.
• Demonstrated experience with cell-based or biochemical assay development.
• Demonstrated understanding of in vitro cancer models and therapeutic mechanisms of actions.
• Experience with characterization and analysis of biotherapeutics (small molecules, antibodies, Fc-fusion proteins, ADCs or other immunoconjugates) is an asset.
• Experience with high-throughput screening assays and workflows is an asset.

Skills and Abilities

• Ability to manage multiple projects, prioritize work, allocate resources, and deliver on deadlines.
• Excellent analytical and problem-solving capabilities.
• Adhere to the highest degree of professional standards and strict confidentiality on matters that require discretion.
• Strong organizational and time management skills, work effectively in a fast paced, fast changing environment.
• Excellent interpersonal skills with the ability to work collaboratively as a member of a cross-functional team; ability to establish and maintain effective working relationships.
• Excellent communication skills, including scientific/technical writing and oral skills. Ability to present data effectively at large team meetings or interdepartmental meetings.
• Demonstrated leadership and mentorship skills.
• Results oriented.
• In depth knowledge of antibody or antibody drug conjugate structure/function.
• Knowledge of GraphPad and FlowJo softwares, or similar software, considered an asset.
• Advanced knowledge and proficiency in the following techniques:
  • Flow cytometry
  • High-content analysis or fluorescence imaging
  • Mammalian tissue culture
  • Immunological/co-culture assays considered an asset